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Tuesday, August 4, 2020 | History

2 edition of Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo. found in the catalog.

Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo.

Donna Monica Debicki

Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo.

by Donna Monica Debicki

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Published .
Written in English


About the Edition

The anti-arrhythmic actions of omega-3 polyunsaturated fatty acids (PUFAs) are widely documented, although the mechanism of this protection is not well understood. The primary objective was to investigate the effects of long chain omega-3 PUFAs on refractoriness, conduction velocity, and defibrillation on a healthy heart in vivo. We infused 0.77ml/kg i.v. Omegaven (EPA + DHA, n=10), Intralipid (vehicle control, n=10), or saline (n=10) over 20 minutes to anesthetised New Zealand White rabbits. Pre and post drug/vehicle treatment, we measured ventricular effective refractory period (VERP: Cycle Length=180, 160, 140msec), shortest cycle length allowing 1:1 capture (SCL), right ventricular monophasic action potential duration at 90% repolarization (MAPD90), QRS duration (stimulus to end of QRS), and QT interval (measured during ventricular pacing). Acute omega-3 PUFA administration has small but significant class III effect in vivo, decreases defibrillation threshold, and may also increase conduction velocity. This combination of effects could possibly account for their anti-arrhythmic actions.

The Physical Object
Pagination110 leaves.
Number of Pages110
ID Numbers
Open LibraryOL19217605M
ISBN 100494074566


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Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo by Donna Monica Debicki Download PDF EPUB FB2